San Isidro is the financial district of Lima, which houses the headquarters of the country's largest banks such as Banco de Crédito del Perú, Interbank, Banco de la Nación, Banco Continental, MiBanco, HSBC, Citibank, Banco Interamericano de Finanzas , Banco Pichincha, Banco de Comercio, Banco GNB and Scotiabank.

The district is also home to the largest insurance companies, which include Rimac Seguros, Mapfre Peru, Interseguro, Pacífico Seguros and La Positiva.

Likewise, several other companies and department stores have their headquarters in San Isidro, among which are Entel, Saga Falabella, Claro, BDO Consulting & Outsourcing, Ernst & Young, McKinsey & Company, Boston Consulting Group, KPMG, GSK, Banco Falabella, Compañía de Minas Buenaventura, Anglo American, Petroperú, Bristol Myers Squibb, Tottus, Boehringer Ingelheim, Ripley, 3M, Brahma, Novartis, PriceWaterhouseCoopers, Deloitte, among others.